Note: this website uses affiliate links for some of the products discussed.
Everyone can benefit from taking an NMN supplement. (And if you do, you'll understand why you need this one...)
If you're into the idea of anti-aging and anti-aging products, then it's quite possible you've heard of "NMN." You may also have heard of some other things in the discussion, too - chemicals your body uses like NR and NAD
I take a supplement called "Liposomal NMN" every day. There are a lot of NMN supplements, but this is the only "Liposomal NMN" formula on the market.
As you read on, you'll see why this one is unique compared to all other NMN supplements out there.
So, just what are NMN, NR and NAD?
Your body wants a lot of something called NAD. This stuff fuels the energy production in your cells.
NAD stands for "nicotinamide adenine dinucleotide. Your body wants LOTS of this NAD.
Your body uses NAD for energy production. NAD fuels the energy factory in your cells. Your body makes NAD but people who supplement are finding great benefit from it.
But here is the trick.
Your body uses NMN to make NAD.
NMN stands for "Nicotinamide Mononucleotide."
Your body produces NMN naturally. It's a "necleotide," which is one of the types of building blocks used to make your DNA.
Your body turns NMN into this NAD inside your cells.
Within your cells, the NMN is converted into another molecule known as "nicotinamide adenine dinucleotide" (NAD).
You might think of NMN as raw material and NAD as the result that your body actually uses to repair your DNA and to "power" your cells.
There are also "NR" supplements.But your body uses NR to make NMN. And it uses NMN to make NAD.
NMN is a precursor to NAD. But there are other "NAD precursors," too. One of them is "NR." You may have heard of this "anti-aging" supplement.
NR (nicotinamide riboside)[2] is another "nucleotide" molecule. And some people take this as a supplement, too.[3]
But the studies point to the fact that the body converts this NR to NMN (and then to NAD). So supplementing with NMN looks like it just "saves a step" for your body to get to increased NAD.
So NR supplements might help a little. But NMN is already partway to where you want to go.
So, you want to take NMN so your body can better make NAD."
Dr. David Sinclair of Harvard Medical School (Harvard University)[1] is one of the pioneering researchers on NMN and how it is used in the body. He is a "longevity specialist" and has done extensive research into this stuff.
He and his research team are looking into the potential benefits of supplementing with NMN, and how it affects longevity, liver conditions, diabetes, brain and heart health and sleep.
So, if NR makes NMN, and NMN turns into NAD, then why not just take NAD supplements?
The answer is simple. Taking NAD as a supplement doesn't really do much. As it turns out, the studies show that taking NAD supplements don't actually do much for these results.
Your body can't get NAD from your gut to where you need it. It needs to make it where it uses it - inside your cells - from NMN.
The interesting thing is that it seems taking NMN supplements, letting the body create its own NAD from the NMN supplements does actually benefit you.
Professor Andrew Salzman (a Harvard Medical School grad and researcher[6] says,
“We now know that [raising NAD levels] can’t be done by delivering NAD either orally or by IV — because NAD has no mechanism for entering the cell.
What Professor Salzman found, though, is that the body can get NMN into the cell where the cell can convert it to NAD.
That's the big difference. That is why you want the NMN for the supplement.
Why do some people take NMN supplements? What benefits do they get from taking this stuff?
Feel younger and more energetic.
Even though your body can produce NMN, taking supplements gives your body more NMN to work with as it goes about converting it to this NAD and building and repairing your cells.
The NAD in your body helps with your energy production, cell repair and healthy responses to stress. And your body burns up that NMN, converting it to NAD to do that.
Longevity
NAD activates "Sirtuins" which are proteins that help with DNA maintenance and repair. Proper maintnenace of your DNA is part and parcel of working against the aging process.
Brain Health
NAD seems to protect the brain from "oxidative stress" (which looks like one of the causes of Alzheimer's disease).
Heart and Circulation Health
Lab tests in mice have shown that high NAD levels actually reversed damage to arteries. This means improvement in cardiovascular diseases.
Cancer Resistance
Higher NAD levels seem to help protect against oxidative stress and DNA damage. (These issues are both connected to cancer development.)
Aging Muscles
Lab experiments have shown that higher NAD levels in mice improve muscle function and endurance.
NMN helps your body keep NAD levels higher as you age.
Since your natural NMN and NAD declines over time, this means that your NAD levels will also decline over time. (Less available NMN means less available for converting to NAD.)
Research shows that people with diabetes and liver disease might have lower levels of NMN and NAD. There are also animal studies that show NMN supplements might help with maintaining heart and brain health as we get older.
What do the studies show about NMN supplements?
Some researchers have gone so far as to describe the benefits of NMN supplementation as "the fountain of youth." [4]
There are some studies with people taking NMN suppplements. They do show some pretty impressive results.
Overweight/Prediabetic Post-Menopausal Women
This study had the subjects taking 250 mg per day of NMN for 10 weeks. At the end of the 10-week study, the women taking the NMN had better "insulin signalling" and sensitivity.[7]
Athletes (Runners)
In this study, they tested 48 runners in total, (ages 27 to 50) taking oral supplements of 300, 600 or 1200 mg per day for 6 weeks (with a placebo group, double-blind study).[5]
At the end of this six week period, the runners on the NMN had greater aerobic capacity. And the higher the dose, the more the increase in capacity.
While it was still an early study, the evidence led the researchers to believe that the NMN had a positive effect on the runner's ability to increase their oxygen uptake.
While the exact mechanism wasn't clear, the results sure seemed to be.
Sleep Studies
There was a sleep study done in Japan with adult seniors (over age 65). The participants were either given a 250 mg dose of NMN or a placebo.[8]
The study ran for 12 weeks.
As far as specific sleep quality, it seems the study didn't really show a specific improvement in sleep. But the participants who got the NMN weren't as drowsy in the afternoon compared to the placebo group. So that does perhaps look like an indirect result equal to improved sleep quality.
Insulin Sensitivity
"insulin sensitivity" is a term that relates to how responsive your cells are to insulin in your system. Improving your insulin sensitivity can improve your resistance to certain diseases like diabetes.[9]
A limited study in Japanese men (10 participants) found that taking NMN increased the levels of NAD in the bloodstream.
Insulin resistance can develop or worsen with age. This is one of the reasons diabetes shows up more as people age.
So this one might not have a direct correlation (yet). But increasing NAD levels in the bloodstream seems to help with insulin sensitivity. So there seems to be good reason to make a connection on this one.
Can you get NMN naturally?
You can get it from what you eat. But you'll have to eat like a horse.
The NIH lists some foods that are rich as natural sources of NMN.[10]. These include avocados, broccoli, cabbage, tomatoes and (raw) beef.
But there is also concern about how much of the NMN you get in your food might get broken down by the stomach acids before it gets to the gut where it can be readily absorbed.
What is "the best" NMN supplement?
This brings us to the important part of this article: the "liposomal" part of "Liposomal NMN."
For all the formulations and additives to the different NMN supplements out there, the studies cited above all seem to indicate that the best absorption is from the gut - AFTER the stomach in the digestive tract.
The "best" NMN supplement is the one that best gets into your system!
The best absorption seems to be through the gut, so you should look for the formula that gets the most of this stuff past your stomach lining.
And that is why...
Why we recommend "Liposomal NMN"
"Liposomal NMN" is a brand of NMN supplement that is specifically formulated in a patented "delivery mechanism" utilizing liposomal technology. Of any of the NMN supplements available on the market today, it's the only one we are aware of that has this particular formulation.
This particular NMN supplement (Liposomal NMN) is packaged in something called a "liposome."
A liposome is "a microscopic artificial vesicle consisting of an aqueous core enclosed in phospholipid molecules, used to convey vaccines, drugs, or other substances to target tissues."[11]
Liposomal NMN is created with a manufacturing process that is patented, and that hides the NMN safely away from your stomach acid so it makes it to the gut where it can be absorbed.
In other words, this "Liposomal NMN" is an NMN supplement where the NMN is delivered in this protective coating that is designed to get past the digestive tract into the gut before this coating breaks down.
This way, the NMN is still intact so your body can absorb it in your gut without it getting destroyed by your stomach acids.
From what we have seen, this particular brand of NMN supplement is the most bioavailable supplement of the ones we've seen so far.
So, although there are several NMN supplements out there, we think this one is the best because it has the best chance of actually making it into your system.
NMN doesn't seem to have any negative side effects.
Because NMN is a naturally occurring substance and is in some of the foods we eat, there were not really any notable side effects worth noting in either the animal studies nor the human trials.
Research has been done with doses of up to 1200 mg per day, and there were no noticeable side effects.
How much is helpful? What Dosage?
The studies all seem to indicate that different levels of dosage are all pretty well tolerated. And they also show that high doses are tolerated well. Higher doses of NMN products and supplements may have a beneficial effect.
The studies are pretty new, as is the whole science of supplementing with NMN. Several studies show that there were differences between 250 mg and 600 mg of NMN. But the results seemed to taper off to the point where there was no noticeable difference going to doses as high as 1200 mg.[12]
The dosage in the Liposomal NMN supplement is 250 mg. But the thing to keep in mind with Liposomal NMN is that it is much more "bioavailable" because of the liposome shield that keeps it safe through your stomach. So that 250 mg delivered safely to your gut because of the liposomal covering seems to equate to a much higher dose without it.
For the best effect, you need "Liposomal NMN."
Even though these studies show favorable results from NMN supplementation, it's always wise to consult with your healthcare professional to make sure you're doing the right thing for your health and for your body.
And if you're going to supplement, it makes sense to use the best supplement you can afford.
As far as "getting your money's worth," it seems that "Liposomal NMN" is probably the best bet for the money, as the 250 mg of NMN is more bioavailable than other formulations without the liposome coating.
Keep in mind that the highest quality of NMN you can take is going to be the one you can best absorb and that your body can best utilize. And that is the reason we recommend Liposomal NMN.
The price?
For what you actually get, it's pretty reasonable.
ONE bottle (a TWO-month's supply) is $69.95 US.
THREE bottles (a SIX-month's supply) is $199.95
SIX bottles (a YEAR's supply) is $349.95 US.
Most people buy the 6-bottle package: if you do it that way, the cost about 95 cents a day.
That's less than a buck a day for a product that research says can actually help your body to reverse aging!
Get Liposomal NMN HERE. 67-day money-back guarantee.
References:
[2] - Healthline - what is NR?
[6] - Andrew Saltzman